nCounter panels available and ready-to-use at Propath

Pre-assembled gene panels are available for gene expression, gene fusion, miRNA, CNV, SNV and protein detection. Custom panels can also be curated for any species for bespoke projects. 

Contact our team of experienced scientists for guidance on the most appropriate panel for your study goals.


Expertly curated, ready-to-use panels are available to accelerate your research


 

nCounter Gene Expression Panels

Pan cancer pathways

Species: Human and Mouse

770 genes for essential cancer pathways including 40 internal reference controls for the human panel & 20 for the mouse panel.


PanCancer Immune Profiling Panels

Species: Human & Mouse

770 immune profiling genes for the identification of different immune cell types, key checkpoint inhibitors, cancer antigens, genes for measuring the immune response & up to 40 internal reference controls.


PanCancer Progression Panel

Species: Human

770 genes involved in cancer progression including angiogenesis, extracellular matrix remodelling (ECM), epithelial to mesenchymal transition (EMT), metastasis including 30 internal reference controls.


Immunology Panels

Species: Human & Mouse

594 human genes or 561 mouse genes for broad-based screening of innate & adaptive immune response for allergy, auto-immune response diseases & infectious disease immune response. Includes up to 15 internal reference controls.


Inflammation Panels

Species: Human & Mouse

255 human genes or 254 mouse genes for focused screening of the inflammation response in general immunology research including allergy, auto-immune diseases & infectious disease immune response. Includes 6 internal reference controls.


Myeloid Innate Immunity Panels

Species: Human & Mouse

696 human genes or 675 mouse genes with emphasis on the myeloid component of innate immunity, which is relevant to cancer, autoimmune, & infectious disease. Includes up to 40 internal reference controls.


NHP Immunology Consortium Panel

Species: Non-Human Primate

770 genes for vaccine testing, toxicity testing & organ transplant studies in non-human primates, including 16 internal reference controls.


Stem Cell Panel

Species: Human

199 genes for the measurement of pluripotency & differentiation, including 6 internal reference controls.


Kinase Panel

Species: Human

535 protein kinase genes known to be differentially expressed in the human kinome with 8 reference controls.


PanCancer IO 360 Panel

Species: Human

750 cancer-related genes involved in the complex interplay between the tumor, microenvironment and immune response including 20 internal reference controls.


Neuropathology Panels

Species: Human & Mouse

760 neuropathology-related genes included in six fundamental themes of neurodegeneration: neurotransmission, neuron-glia interaction, neuroplasticity, cell structure integrity, neuroinflammation and metabolism including 10 internal reference controls.

 

miRNA Expression Panels - from miRBase v 21

nCounter Human v3 miRNA

Species: Human

>800 human miRNAs with 20 internal reference controls & 5 mRNA probes.


nCounter Mouse v1.5 miRNA

Species: Mouse

>600 mouse and mouse-associated viral miRNAs with 20 internal controls & 4 mRNA probes.


nCounter Rat v1.5 miRNA

Species: Rat

>400 rat miRNAs derived from miRBase with 20 internal reference controls & 4 mRNA probes.

 

CNV- Copy Number Variation

nCounter Human Cancer CN Panel

Species: Human

87 most commonly amplified or deleted copy numbers in cancer.


nCounter Human Karyotyping Panel

Species: Human

24 human chromosomes, 388 Individual loci for gross chromosomes abnormalities.

 

RNA Panels

nCounter Vantage 3D Adaptive Immunity Panel

Species: Human

180 genes to study T & B cell activation and signalling molecules, plus 12 internal reference controls.


nCounter Vantage 3D Innate Immunity Panel

Species: Human

180 genes involved in host response, bacterial sensing, inflammation. Includes Toll-like receptor signaling, and related cytokines, plus 12 internal reference controls.


nCounter Vantage 3D Cancer Metabolism Panel

Species: Human

180 unique genes related to cancer metabolism, plus 12 internal reference controls.


nCounter Vantage 3D Intracellular Signalling Panel

Species: Human

180 unique genes related to signalling pathways in cancer immunology, plus 12 internal reference controls.


nCounter Vantage 3D Cellular Profiling Panel

Species: Human

180 unique genes whose relative expression level is indicative of specific cell types, plus 12 internal reference controls.


nCounter Vantage 3D Wnt Pathways Panel

Species: Human


180 unique genes related to the Wnt signalling pathways ( B-catenin, PCP and Calcium-Ion dependent pathways), plus 12 internal reference controls.

nCounter Vantage 3D DNA Damage and Repair Panel

Species: Human

180 unique genes related to DNA damage & repair pathways, including base excision repair, nucleotide excision repair, mismatch repair, trans-lesion synthesis, and other repair processes genes. In addition, 12 internal reference controls.


nCounter Vantage 3D MAPK-PI3K Pathways Panel

Species: Human

192 genes that measure activation of the MAPK and/or PI3K pathways, plus 12 internal reference controls.


nCounter Vantage 3D RNA Heme Panel

Species: Human

180 hematologic oncology related human genes, plus 12 internal reference controls.

 

Protein Panels

nCounter Vantage 3D Immune Cell Profiling for cell suspensions

Species: Human

30 immune cell surface proteins including CD4, CD8, PDL-1, plus 3 internal reference controls.


nCounter Vantage 3D Immune Cell Signalling for cell suspensions

Species: Human

30 intracellular immune cell signalling proteins including IL-2, IL-6, FOXP3, plus 3 internal reference controls.


nCounter Vantage 3D Solid Tumour Signalling Pathways for cell lysates

Species: Human

28 solid tumour signalling pathway total and phospho-protein targets including AKT, MAPK, PRAS40, plus 3 internal reference controls.


nCounter Vantage 3D Solid Tumour Signalling Pathways for FFPE

Species: Human

26 key solid tumour signalling protein targets listed above, plus 3 internal reference controls.

 

DNA (Single Nucleotide Variants) Panels

nCounter Vantage 3D SNV Solid Tumour

Species: Human

104 actionable and high-frequency SNV and INDELS in 25 key solid tumour genes.

 

Lung and Leukaemia Gene Fusion Panels

nCounter Vantage 3D Lung Gene Fusion Panel

Species: Human

63 probes: 35 for specific fusion detection, 24 for positional gene expression imbalance detection, and 4 internal reference controls.


nCounter Vantage 3D Leukaemia Gene Fusion Panel

Species: Human

42 probes: 27 for specific fusion detection, 12 leukaemia biomarkers, and 3 internal reference controls.


 

PanCancer IO 360 panel

Accelerate your immuno-oncology research with rapid evaluation of immune evasion and predictive signatures with the Nanostring PanCancer IO 360 panel. 

Run at Propath’s facility in the UK on the Nanostring nCounter platform, this expertly curated panel of 770 genes provides powerful insights into:  signalling pathways that cause a tumour; the tumour’s microenvironment; the immune system response; and tumour progression and metastasis.

Key features of this panel:

  • Comprehensive gene panel of 770 targets spanning 16 key immuno-oncology pathways
  • Assessment of cellular abundance and populations across 14 different cell types
  • 47 signatures including the Tumour Inflammation Signature
  • Additional access to proprietary signatures including the Tumour Inflammation Signature
  • Raw data or data analysis service providing publication ready figures and statistical analysis
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Assessing key areas of tumour biology

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Calculation of 47 gene signatures carefully curated to measure biological variables crucial to the tumour-immune interaction. Validated and research signatures are enriched with predictive genes incorporating seven different biological functions to measure:

  • Antigen availability
  • Structural barriers to immune infiltration
  • Inhibitory signalling
  • Inhibitory metabolism
  • Pro-immune signalling
  • Killing of tumour cells
  • Tumour receptiveness to immune signalling
  • Tumour proliferation
  • Apoptosis

Data Output

Propath can provide detailed signature analysis services for the PanCancer IO 360 panel for single sample analysis or much larger cohorts. A report will provide information on all 47 signatures included in the panel and analysis for the identification of novel signatures.

Tumour inflammation signature

This 18-gene signature, also included in the PanCancer IO 360 panel, measures activity known to be associated with response to PD-1/PD-L1 inhibitors pathway blockade. TIS score is available as an additional data output.