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From Biology

to Data®

We help our clients accelerate their drug research by translating the biology of living systems into meaningful data.
‍
Explore how our services in spatial biology, molecular pathology and histopathology can support your next study.

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Illustration conveying 'from Biology to Data'

‌The Spatial Biology CRO®

‌Propath’s spatial biology platforms allow you to explore which cells are present, where they are located in tissue, their biomarker co-expression, and how they organise to influence the tissue microenvironment.

Contact us to discuss how our solutions in spatial biology can help your next study.

Contact
Schedule a callGet in touch
‌The Spatial Biology CRO
GLP Compliant
GCP Compliant
HTA Compliant

Trusted specialists for biopharma R&D

We are specialists in molecular pathology and histopathology for biopharma R&D. It’s what we’ve been doing for over thirty years. Trusted by our clients – small and large – across the world.

We believe the details matter: offering genuine expertise, ensuring robust Quality Assurance and being precise in our work.

Explore our services or contact us to get started on your study.

Genomics and Proteomics icon

Genomics and Proteomics

  • Accredited NanoString Core Lab
  • Spatial transcriptomics
  • Ultra-high plex sequential immunofluorescence
  • Gene expression analysis
  • RNA/DNA extraction
Learn more
Molecular Pathology icon

Molecular Pathology

  • GLP/GCP compliant IHC & FISH
  • Multiplex method development
  • Antibody TCR studies
  • RNA Scope
Learn more
Histopathology icon

Histopathology

  • GLP/GCP compliant histology
  • Histopathological examination
  • Clinical trial support
  • Digital slide scanning
  • Digital image analysis
Learn more
View all our services

Nanostring ncounter service

Precisely quantify up to 800 genes or proteins in a single sample

  • From sample to data within as little as three weeks, all managed by Propath
  • Optimised for difficult samples, including FFPE tissue
  • Sensitive and precise, with no amplification bias
Explore more
Precisely quantify up to 800 genes or proteins in a single sample
Spatially resolve highly multiplexed RNA and protein markers

Spatial Transcriptonomics

Spatially resolve highly multiplexed RNA and protein markers

  • Multiplex up to 18,000 RNA or 800 protein targets per biological region of interest
  • Compatible with FFPE and frozen clinical samples
  • Fully managed as a service by Propath – from sample prep to data analysis – with robust QA and rapid turnaround
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Sequential Immunofluorescence

‌Study cells in context with ultra high-plex IHC

  • ‌Up to 40 protein markers on a single tissue section
  • ‌Add your target markers to our existing validated panels
  • ‌20 slides of 40-plex per week; or 40 slides of 10-plex
Explore more
‌Study cells in context with ultra high-plex IHC

High-plex immunofluorescence in practice: representative images produced at Propath

5 minute webinars

Propath's 5 minute Webinars

Gain useful insights and knowledge in just five minutes

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Duration: 5 minutes

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Duration: 5 minutes

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Duration: 5 minutes
Experienced
Expertise and know-how gained across forty years and thousands of successfully completed studies
Trusted
Trusted by sponsors globally, including 6 of the world’s top ten biopharma companies
GLP/GCP compliant
Robust QA systems and procedures run through everything we do
Award-winning
Proud recipient of the Queen’s Award for Enterprise, recognising our contribution to the life sciences industry
About us

What our clients say

"
We have worked with Propath for the last two years on a variety of research projects, including both routine analyses and development of novel methods. They have been an excellent partner, always delivering work of a very high quality on time and to agreed budgets.
"
Nicholas Glanville PhD, Director, Preclinical Research
Prokarium Ltd
Quoted with consent of author
"
We have worked with Propath on a number of IHC projects and have found them to provide supportive, proactive communication with high levels of scientific expertise. The work they have performed for us has been of a high standard and enhanced the data in our research programmes.
"
Senior Director
Translational Medicine
Quoted with consent of author
"
Propath is a company with whom I look forward to working with. I have worked with Propath for many years and they have assisted us with several studies. Communication with regards to project timelines is particularly excellent which facilitates the smooth running of projects from start to finish. My contact with their staff is always professional and courteous. The quality of their work is extremely high, and delivery of results is timely and accurate. It was a pleasure to work with them.
"
Principal Scientist
Large Biopharma Company
Quoted with consent of author

A selection of our work

01
‌Human lymphoid tissue section showing six channels from a 10-plex immunofluorescence stain, produced on Propath’s Lunaphore Comet platform.

CD4 green, CD8 orange, PD-1 red, PD-L1 magenta, FOXP3 white, DAPI blue
‌Human lymphoid tissue section showing six channels from a 10-plex immunofluorescence stain, produced on Propath’s Lunaphore Comet platform.
02
‌The very same section of human lymphoid tissue as previous image but now showing another five channels of the same 10-plex immunofluorescence stain.

CD20 green, CD3 red, CK magenta, Ki67 white, CD68 orange
Lymph node slide showing five channels of the 10-plex immunofluorescence stain.
03
‌Non-small-cell lung carcinoma  section with four colour fluorescent morphology stain.Image highlights epithelial tumour and immune infiltrate with region of interest and tissue segmentation overlays.

DNA, CD45, CD68, PanCK
‌Non-small-cell lung carcinoma  section with four colour fluorescent morphology stain.Image highlights epithelial tumour and immune infiltrate with region of interest and tissue segmentation overlays.
04
‌Dual immunofluorescent staining of pSMAD (Cy5 fluorophore, orange) and a proprietary biomarker (FAM fluorophore, green) in pancreatic cancer tissue.

Strong positive pSMAD staining present in pancreatic islets, with some areas of co-localisation present indicated by bright yellow staining. DAPI nuclear stain is shown in blue.
‌Dual immunofluorescent staining of pSMAD (Cy5 fluorophore, orange) and a proprietary biomarker (FAM fluorophore, green) in pancreatic cancer tissue.
05
‌GFAP (glial fibrillary acidic protein) staining of glial cells in the hippocampus.

Chromogenic DAB staining.
‌GFAP (glial fibrillary acidic protein) staining of glial cells in the hippocampus.
06
‌Chromogenic ISH staining of human NPY2 receptor in an animal model brain.

Only the human NPY2 receptor is specifically detected and not the endogenous NPY2 receptor.
‌Chromogenic ISH staining of human NPY2 receptor in an animal model brain.
07
‌Spatial protein and RNA analysis of a section of colorectal carcinoma using the NanoString GeoMx with IHC overlays.

Top left: GeoMx ROI selection for protein panel

Top right: GeoMx ROI selection for Whole Transcriptome RNA panel

Middle right:  Dual IHC stain for CD4 in purple and CD8 in yellow

Bottom right: IHC stain for PD-LI
‌Spatial protein and RNA analysis of a section of colorectal carcinoma using the NanoString GeoMx with IHC overlays.
08
‌Jones’ methenamine silver stain in mini-pig kidney demonstrating basement membranes.
‌Jones’ methenamine silver stain in mini-pig kidney demonstrating basement membranes.
09
‌Masson’s Trichrome stain with aniline blue counterstain of kidney, demonstrating collogen in blue/dark blue; muscle red blood cells and fibrin in red; and nuclei in blue/black.
‌Masson’s Trichrome stain with aniline blue counterstain of kidney, demonstrating collogen in blue/dark blue; muscle red blood cells and fibrin in red; and nuclei in blue/black.
10
‌H&E stain of skin and mammary gland, showing epidermis, dermis, hair follicles, fat cells and mammary gland.
‌H&E stain of skin and mammary gland, showing epidermis, dermis, hair follicles, fat cells and mammary gland.
11
‌H&E stain of testis/epididymis demonstrating testis (seminiferous tubules containing spermatocytes), interstitial Leydig cells; and epididymis: initial segment (dense tubular area above head), head (caput), corpus(middle), caput (tail).
‌H&E stain of testis/epididymis demonstrating testis (seminiferous tubules containing spermatocytes), interstitial Leydig cells; and epididymis: initial segment (dense tubular area above head), head (caput), corpus(middle), caput (tail).
12
‌Verhoff’s Van Gieson stain of aorta demonstrating aorta, tunica adventitia, tunica media, tunica intima, with collagen in red and elastic fibres in black.
‌Verhoff’s Van Gieson stain of aorta demonstrating aorta, tunica adventitia, tunica media, tunica intima, with collagen in red and elastic fibres in black.
13
‌H&E stain of eye demonstrating cornea, iris, lens, retina, choroid, optic nerve and Hardarian gland.
‌H&E stain of eye demonstrating cornea, iris, lens, retina, choroid, optic nerve and Hardarian gland.

News

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Propath presents a new approach for AI-driven ROI selection for GeoMx DSP analysis at SITC 2023

Working with our partners at Visiopharm and NanoString, the team at Propath UK have today published a poster at SITC 2023 demonstrating a new approach to streamline the workflow for ROI/AOI selection on GeoMx® DSP slides.

Taking spatial transcriptomics to the next level: Propath UK launches NanoString CosMx single-cell spatial analysis as a commercial service

The CosMx is a powerful new platform for spatial transcriptomics and proteomics, providing high-plex in-situ analysis at cellular and subcellular resolution. The platform enables researchers to investigate morphologically-intact tissues at unprecedented plex, resolution and cell numbers.

Propath partners with Lunaphore to offer hyper-plex immunofluorescence staining

Propath and Lunaphore form partnership to offer hyper-plex spatial proteomics

Case Studies

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Outsourced R&D - Done better.

At Propath we approach biopharma R&D differently. Say goodbye to Large CRO frustrations –and hello to a more responsive, agile and efficient level of service.
Schedule a callGet in touch
AboutOur workWhat our clients sayNews
Solutions for Spatial BiologyNanoString CosMxNanoString GeoMxLunaphore Comet‌Akoya PhenoCyclerGene ExpressionNanoString nCounter‌RUO PAM50 Breast Cancer Analysis
PathologyGCP Compliant RNAscope™GLP/GCP Compliant IHCGLP/GCP Compliant HistologyBiomarker Method Development
GCP Compliant Image Analysis
Contact
+44 (0) 1432 354 052 askpropath@propath.co.uk
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