Propath - Specialists in molecular pathology and histopathology

Trusted specialists for biopharma R&D

We are specialists in molecular pathology and histopathology for biopharma R&D. It’s what we’ve been doing for over thirty years. Trusted by our clients – small and large – across the world.

We believe the details matter: offering genuine expertise, ensuring robust Quality Assurance and being precise in our work.

Explore our services or contact us to get started on your study.

Genomics and Proteomics

Accredited NanoString Core Lab
Spatial transcriptomics
Ultra-high plex sequential immunofluorescence
Gene expression analysis
RNA/DNA extraction

Molecular Pathology

GLP/GCP compliant IHC & FISH
Multiplex method development
Antibody TCR studies
RNA Scope

Histopathology

GLP/GCP compliant histology
Histopathological examination
Clinical trial support
Digital slide scanning
Digital image analysis

Nanostring ncounter service

Precisely quantify up to 800 genes or proteins in a single sample

From sample to data within as little as three weeks, all managed by Propath
Optimised for difficult samples, including FFPE tissue
Sensitive and precise, with no amplification bias

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Precisely quantify up to 800 genes or proteins in a single sample

Spatial Transcriptonomics

Spatially resolve highly multiplexed RNA and protein markers

Multiplex up to 18,000 RNA or 800 protein targets per biological region of interest
Compatible with FFPE and frozen clinical samples
Fully managed as a service by Propath – from sample prep to data analysis – with robust QA and rapid turnaround

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Sequential Immunofluorescence

‌Study cells in context with ultra high-plex IHC

‌Up to 40 protein markers on a single tissue section
‌Add your target markers to our existing validated panels
‌20 slides of 40-plex per week; or 40 slides of 10-plex

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‌Study cells in context with ultra high-plex IHC

High-plex immunofluorescence in practice: representative images produced at Propath

Propath's 5 minute Webinars

Gain useful insights and knowledge in just five minutes

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Duration: 5 minutes

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Duration: 5 minutes

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Duration: 5 minutes

Experienced

Expertise and know-how gained across forty years and thousands of successfully completed studies

Trusted

Trusted by sponsors globally, including 6 of the world’s top ten biopharma companies

GLP/GCP compliant

Robust QA systems and procedures run through everything we do

Award-winning

Proud recipient of the Queen’s Award for Enterprise, recognising our contribution to the life sciences industry

About us

Advanced platforms for spatial biology available today at Propath

‌Our experience across a range of platforms for spatial biology allows us to recommend the most appropriate platform for each research project.

We understand the strengths and limitations of each platform – and how to get the best out of them.

RNAScope and BaseScope

Robust in situ hybridization technology for rapid quantification of any RNA target in any tissue with spatial context

‌Validated for GCP studies

PhenoCycler and PhenoImager

High plex single-cell spatial phenotyping; and focused mIF panels for high-throughput translational research

‌Validated for GCP studies

COMET

Highly multiplexed sequential immunofluorescence for up to 40 protein on a single slide

‌Validated for GCP studies

PhenoCycler and PhenoImager

High-plex and focussed mIF panels supporting discovery and translational studies

‌Validated for GCP studies

Xenium

Targeted, scalable spatial transcriptomics and multi-omics panels at subcellular resolution

‌Validated for GCP studies

nCounter, GeoMx and Cosmx

Integrated spatial multi-omics including up to whole transcriptome profiling from tissue to sub-cellular resolution

‌Validated for GCP studies

Proximity Ligation Assays

Automated PLA assays for the detection of protein-protein interactions and post- translational modifications

‌Validated for GCP studies

nCounter, GeoMx and Cosmx

Integrated spatial multi-omics including up to whole transcriptome profiling from tissue to sub-cellular resolution

‌Validated for GCP studies

RNAscope and COMET

High-plex and focussed multi-omic mIF panels supporting discovery and translational studies

‌Validated for GCP studies

What our clients say

"

Again I would like to thank you very much for your excellent work. It is really a pleasure to look at the slides, very nice stain and very high quality!

"

Senior Veterinary Pathologist

Tier I German pharma customer following completion of GLP histology study

Quoted with consent of author

"

Propath is a company with whom I look forward to working with. I have worked with Propath for many years and they have assisted us with several studies. Communication with regards to project timelines is particularly excellent which facilitates the smooth running of projects from start to finish. My contact with their staff is always professional and courteous. The quality of their work is extremely high, and delivery of results is timely and accurate. It was a pleasure to work with them.

"

Principal Scientist

Large Biopharma Company

Quoted with consent of author

"

We have worked with Propath on a number of IHC projects and have found them to provide supportive, proactive communication with high levels of scientific expertise. The work they have performed for us has been of a high standard and enhanced the data in our research programmes.

"

Senior Director

Translational Medicine

Quoted with consent of author

A selection of our work

01

‌Human lymphoid tissue section showing six channels from a 10-plex immunofluorescence stain, produced on Propath’s Lunaphore Comet platform.

CD4 green, CD8 orange, PD-1 red, PD-L1 magenta, FOXP3 white, DAPI blue

02

‌The very same section of human lymphoid tissue as previous image but now showing another five channels of the same 10-plex immunofluorescence stain.

CD20 green, CD3 red, CK magenta, Ki67 white, CD68 orange

Lymph node slide showing five channels of the 10-plex immunofluorescence stain.

03

‌Non-small-cell lung carcinoma section with four colour fluorescent morphology stain.Image highlights epithelial tumour and immune infiltrate with region of interest and tissue segmentation overlays.

DNA, CD45, CD68, PanCK

04

‌Dual immunofluorescent staining of pSMAD (Cy5 fluorophore, orange) and a proprietary biomarker (FAM fluorophore, green) in pancreatic cancer tissue.

Strong positive pSMAD staining present in pancreatic islets, with some areas of co-localisation present indicated by bright yellow staining. DAPI nuclear stain is shown in blue.

05

‌GFAP (glial fibrillary acidic protein) staining of glial cells in the hippocampus.

Chromogenic DAB staining.

06

‌Chromogenic ISH staining of human NPY2 receptor in an animal model brain.

Only the human NPY2 receptor is specifically detected and not the endogenous NPY2 receptor.

07

‌Spatial protein and RNA analysis of a section of colorectal carcinoma using the NanoString GeoMx with IHC overlays.

Top left: GeoMx ROI selection for protein panel

Top right: GeoMx ROI selection for Whole Transcriptome RNA panel

Middle right: Dual IHC stain for CD4 in purple and CD8 in yellow

Bottom right: IHC stain for PD-LI

08

‌Jones’ methenamine silver stain in mini-pig kidney demonstrating basement membranes.

09

‌Masson’s Trichrome stain with aniline blue counterstain of kidney, demonstrating collogen in blue/dark blue; muscle red blood cells and fibrin in red; and nuclei in blue/black.

10

‌H&E stain of skin and mammary gland, showing epidermis, dermis, hair follicles, fat cells and mammary gland.

11

‌H&E stain of testis/epididymis demonstrating testis (seminiferous tubules containing spermatocytes), interstitial Leydig cells; and epididymis: initial segment (dense tubular area above head), head (caput), corpus(middle), caput (tail).

12

‌Verhoff’s Van Gieson stain of aorta demonstrating aorta, tunica adventitia, tunica media, tunica intima, with collagen in red and elastic fibres in black.

13

‌H&E stain of eye demonstrating cornea, iris, lens, retina, choroid, optic nerve and Hardarian gland.

News

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Propath presents a new approach for AI-driven ROI selection for GeoMx DSP analysis at SITC 2023

Working with our partners at Visiopharm and NanoString, the team at Propath UK have today published a poster at SITC 2023 demonstrating a new approach to streamline the workflow for ROI/AOI selection on GeoMx® DSP slides.

Taking spatial transcriptomics to the next level: Propath UK launches NanoString CosMx single-cell spatial analysis as a commercial service

The CosMx is a powerful new platform for spatial transcriptomics and proteomics, providing high-plex in-situ analysis at cellular and subcellular resolution. The platform enables researchers to investigate morphologically-intact tissues at unprecedented plex, resolution and cell numbers.

Propath partners with Lunaphore to offer hyper-plex immunofluorescence staining

Propath and Lunaphore form partnership to offer hyper-plex spatial proteomics

Case Studies

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Outsourced R&D - Done better.

At Propath we approach biopharma R&D differently. Say goodbye to Large CRO frustrations –and hello to a more responsive, agile and efficient level of service.

Schedule a call Get in touch

From Biology

to Data®

‌The Spatial Biology CRO®

Trusted specialists for biopharma R&D

Genomics and Proteomics

Molecular Pathology

Histopathology

Nanostring ncounter service

Precisely quantify up to 800 genes or proteins in a single sample

Spatial Transcriptonomics

Spatially resolve highly multiplexed RNA and protein markers

Sequential Immunofluorescence

‌Study cells in context with ultra high-plex IHC

High-plex immunofluorescence in practice: representative images produced at Propath

Propath's 5 minute Webinars

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Spatial transcriptonomics: how researchers are using it to reveal new pathways in oncology research

Experienced

Trusted

GLP/GCP compliant

Award-winning

Advanced platforms for spatial biology available today at Propath

What our clients say

A selection of our work

News

Propath presents a new approach for AI-driven ROI selection for GeoMx DSP analysis at SITC 2023

Taking spatial transcriptomics to the next level: Propath UK launches NanoString CosMx single-cell spatial analysis as a commercial service

Propath partners with Lunaphore to offer hyper-plex immunofluorescence staining

Case Studies

Consequuntur

Necessitatibus Natus

Et Quia

Outsourced R&D - Done better.